Journal article
RNA-free and ribonucleoprotein-associated influenza virus polymerases directly bind the serine-5 phosphorylated carboxyl-terminal domain of host RNA polymerase II
- Abstract:
-
Influenza viruses subvert the transcriptional machinery of their hosts to synthesise their own viral mRNA. Ongoing transcription by cellular RNA polymerase II (Pol II) is required for viral mRNA synthesis. By a process known as cap-snatching, the virus steals short 5ʹ capped RNA fragments from host capped RNAs and uses these to prime viral transcription. An interaction between the influenza A virus RNA polymerase and the C-terminal domain (CTD) of the large subunit of Pol II has been establis...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ European Research Council
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Funding agency for:
Martinez-Alonso, M
Grant:
FP7/2007-2013) Marie Curie Intra European Fellowship
+ Wellcome Trust
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Funding agency for:
Hengrung, N
Grant:
Studentship 092931/Z/10/Z
Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Journal of Virology Journal website
- Publication date:
- 2016-04-20
- Acceptance date:
- 2016-04-13
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
Item Description
- Pubs id:
-
pubs:616079
- UUID:
-
uuid:366ad87c-1765-4616-812c-0725718ffd9a
- Local pid:
- pubs:616079
- Source identifiers:
-
616079
- Deposit date:
- 2016-04-15
Terms of use
- Copyright holder:
- American Society for Microbiology
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Martinez-Alonso et al. All Rights Reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. This is the author accepted manuscript following peer review version of the article. The final version may be available online from American Society For Microbiology at: https://doi.org/10.1128/JVI.00494-16
- Licence:
- CC Attribution (CC BY)
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