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Nuclear IGF1R interacts with regulatory regions of chromatin to promote RNA Polymerase II recruitment and gene expression associated with advanced tumor stage

Abstract:

Internalization of ligand-activated type I IGF receptor (IGF1R) is followed by recycling to the plasma membrane, degradation or nuclear translocation. Nuclear IGF1R reportedly associates with clinical response to IGF1R inhibitory drugs, yet its role in the nucleus is poorly characterized. Here, we investigated the significance of nuclear IGF1R in clinical cancers and cell line models. In prostate cancers, IGF1R was predominantly membrane localized in benign glands, while malignant epithelium ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/0008-5472.CAN-17-3498

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0001-9149-0831
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
78
Issue:
13
Pages:
3497-3509
Publication date:
2018-05-07
Acceptance date:
2018-04-26
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Pmid:
29735545
Source identifiers:
847717
Language:
English
Keywords:
Pubs id:
pubs:847717
UUID:
uuid:365abf0c-098a-4c84-b28d-267e6800d029
Local pid:
pubs:847717
Deposit date:
2019-05-20

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