Journal article
Immune phenotype and function of NK and T cells in chronic hepatitis C patients who received a single dose of anti-miR-122, RG-101.
- Abstract:
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MicroRNA-122 (miR-122) is an important host factor for the hepatitis C (HCV) virus. Treatment with RG-101, a GalNAc conjugated anti-miR-122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic hepatitis C (CHC) infection. Here, we analyzed the effects of RG-101 therapy on antiviral immunity. 32 CHC patients HCV genotype 1, 3 and 4 received a single subcutaneous administration with RG-101 at 2 mg/kg (n=14), 4 mg/kg (n=14) or placebo (n=2 per dosing group). P...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 749.7KB)
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- Publisher copy:
- 10.1002/hep.29148
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Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Klenerman, P
Grant:
U19AI082630
+ National Institutes of Health
More from this funder
Funding agency for:
Klenerman, P
Grant:
U19AI082630
+ National Institute of Health Research
More from this funder
Funding agency for:
Klenerman, P
Grant:
U19AI082630
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Hepatology Journal website
- Volume:
- 66
- Issue:
- 1
- Pages:
- 57–68
- Publication date:
- 2017-03-01
- Acceptance date:
- 2017-03-03
- DOI:
- ISSN:
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1527-3350
- Source identifiers:
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686131
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:686131
- UUID:
-
uuid:36413f7a-96c8-4f0f-92e5-e2802854e7c9
- Local pid:
- pubs:686131
- Deposit date:
- 2017-03-27
Terms of use
- Copyright holder:
- Barnes et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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