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Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia

Abstract:

Nuclear factor I-C (NFIC) belongs to a family of NFI transcription factors that binds to DNA through CAATT-boxes and are involved in cellular differentiation and stem cell maintenance. Here we show NFIC protein is significantly overexpressed in 69% of acute myeloid leukemia patients. Examination of the functional consequences of NFIC overexpression in HSPCs showed that this protein promoted monocytic differentiation. Single-cell RNA sequencing analysis further demonstrated that NFIC overexpre...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1038/s41375-022-01801-z

Authors


Publisher:
Springer Nature
Journal:
Leukemia More from this journal
Volume:
37
Issue:
2
Pages:
276-287
Place of publication:
England
Publication date:
2022-12-26
Acceptance date:
2022-12-15
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
Pmid:
36572750
Language:
English
Keywords:
Pubs id:
1318179
Local pid:
pubs:1318179
Deposit date:
2024-01-10

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