Journal article
Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia
- Abstract:
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Nuclear factor I-C (NFIC) belongs to a family of NFI transcription factors that binds to DNA through CAATT-boxes and are involved in cellular differentiation and stem cell maintenance. Here we show NFIC protein is significantly overexpressed in 69% of acute myeloid leukemia patients. Examination of the functional consequences of NFIC overexpression in HSPCs showed that this protein promoted monocytic differentiation. Single-cell RNA sequencing analysis further demonstrated that NFIC overexpre...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 5.3MB, Terms of use)
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- Publisher copy:
- 10.1038/s41375-022-01801-z
Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Leukemia More from this journal
- Volume:
- 37
- Issue:
- 2
- Pages:
- 276-287
- Place of publication:
- England
- Publication date:
- 2022-12-26
- Acceptance date:
- 2022-12-15
- DOI:
- EISSN:
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1476-5551
- ISSN:
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0887-6924
- Pmid:
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36572750
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1318179
- Local pid:
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pubs:1318179
- Deposit date:
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2024-01-10
Terms of use
- Copyright holder:
- Rastogi et al
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http:// creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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