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Thesis

Applying single cell-based technologies to the characterisation of human haematopoietic stem cell heterogeneity

Abstract:

Haematopoiesis is essential for all vertebrate life. It involves the generation of terminally differentiated blood cells from a small pool of self-renewing multipotent haematopoietic stem cells (HSCs) through a series of lineage-restricted progenitors. HSCs form the basis of bone marrow (BM) transplantations and enable the treatment of patients with genetic blood disorders and leukaemia. It has long been assumed that individual HSCs have the capacity to produce all blood lineages in equal pro...

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Division:
MSD
Department:
RDM
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0002-0544-735X
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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