Journal article
Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability
- Abstract:
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In sympathetic neurons innervating the heart, action potentials activate voltage-gated Ca2+ channels and evoke Ca2+ entry into presynaptic terminals triggering neurotransmitter release. Binding of transmitters to specific receptors stimulates signal transduction pathways that cause changes in cardiac function. The mechanisms contributing to presynaptic Ca2+ dynamics involve regulation of endogenous Ca2+ buffers, in particular the endoplasmic reticulum, mitochondria and cyclic nucleotide targe...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, 214.6KB)
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- Publisher copy:
- 10.1016/j.semcdb.2019.01.010
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Seminars in Cell and Developmental Biology Journal website
- Volume:
- 94
- Pages:
- 20-27
- Publication date:
- 2019-01-23
- Acceptance date:
- 2019-01-14
- DOI:
- EISSN:
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1096-3634
- ISSN:
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1084-9521
- Pmid:
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30658154
- Source identifiers:
-
965407
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:965407
- UUID:
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uuid:35e98975-4593-4d63-9791-534db7f69dfd
- Local pid:
- pubs:965407
- Deposit date:
- 2019-04-11
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2019
- Rights statement:
- © 2019 Elsevier Ltd. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.semcdb.2019.01.010
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