Journal article
Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity
- Abstract:
-
Receptor phosphorylation is thought to be tightly regulated because phosphorylated receptors initiate signaling cascades leading to cellular activation. The T cell antigen receptor (TCR) on the surface of T cells is phosphorylated by the kinase Lck and dephosphorylated by the phosphatase CD45 on multiple immunoreceptor tyrosine-based activation motifs (ITAMs). Intriguingly, Lck sequentially phosphorylates ITAMs and ZAP-70, a cytosolic kinase, binds to phosphorylated ITAMs with differential af...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 475.4KB)
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- Publisher copy:
- 10.1371/journal.pcbi.1003004
Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Computational Biology Journal website
- Volume:
- 9
- Issue:
- 3
- Pages:
- ARTN e1003004
- Publication date:
- 2013-03-28
- Acceptance date:
- 2013-02-05
- DOI:
- EISSN:
-
1553-7358
- ISSN:
-
1553-734X
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:35cfae67-6fa1-4c47-b7f1-903cacab8b2e
- Local pid:
- pubs:387503
- Source identifiers:
-
387503
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Mukhopadhyay et al
- Copyright date:
- 2013
- Notes:
- Copyright: © 2013 Mukhopadhyay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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