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Pushing the limits of sulfur SAD phasing: de novo structure solution of the N-terminal domain of the ectodomain of HCV E1.

Abstract:

Single-wavelength anomalous dispersion of S atoms (S-SAD) is an elegant phasing method to determine crystal structures that does not require heavy-atom incorporation or selenomethionine derivatization. Nevertheless, this technique has been limited by the paucity of the signal at the usual X-ray wavelengths, requiring very accurate measurement of the anomalous differences. Here, the data collection and structure solution of the N-terminal domain of the ectodomain of HCV E1 from crystals that d...

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Publication status:
Published

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Publisher copy:
10.1107/s139900471401339x

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Publisher:
International Union of Crystallography
Journal:
Acta crystallographica. Section D, Biological crystallography
Volume:
70
Issue:
Pt 8
Pages:
2197-2203
Publication date:
2014-08-05
DOI:
EISSN:
1399-0047
ISSN:
0907-4449
URN:
uuid:35bb94ad-08df-4897-b508-cf3c95305063
Source identifiers:
478911
Local pid:
pubs:478911
Language:
English
Keywords:

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