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The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Abstract:

Membranes in cells have defined distributions of lipids in each leaflet, controlled by lipid scramblases and flip/floppases. However, for some intracellular membranes such as the endoplasmic reticulum (ER) the scramblases have not been identified. Members of the TMEM16 family have either lipid scramblase or chloride channel activity. Although TMEM16K is widely distributed and associated with the neurological disorder autosomal recessive spinocerebellar ataxia type 10 (SCAR10), its location in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-11753-1

Authors


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Role:
Author
ORCID:
0000-0001-5477-6777
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
ORCID:
0000-0001-9661-2607
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications
Volume:
10
Article number:
3956 (2019)
Publication date:
2019-09-02
Acceptance date:
2019-08-01
DOI:
EISSN:
2041-1723
Pmid:
31477691
Source identifiers:
1049283
Language:
English
Keywords:
Pubs id:
pubs:1049283
UUID:
uuid:358f687c-d7da-45fe-aa8f-bd8c91202ecc
Local pid:
pubs:1049283
Deposit date:
2019-09-18

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