Journal article
Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial
- Abstract:
-
Salmonella enterica serovar Typhi (S Typhi) is responsible for an estimated 20 million infections and 200 000 deaths each year in resource poor regions of the world. Capsular Vi-polysaccharide-protein conjugate vaccines (Vi-conjugate vaccines) are immunogenic and can be used from infancy but there are no efficacy data for the leading candidate vaccine being considered for widespread use. To address this knowledge gap, we assessed the efficacy of a Vi-tetanus toxoid conjugate vaccine using an ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 419.4KB)
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- Publisher copy:
- 10.1016/s0140-6736(17)32149-9
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Lancet Journal website
- Volume:
- 390
- Issue:
- 10111
- Pages:
- 2472-2480
- Publication date:
- 2017-09-28
- Acceptance date:
- 2017-07-26
- DOI:
- EISSN:
-
1474-547X
- ISSN:
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0140-6736
- Pubs id:
-
pubs:732517
- URN:
-
uri:3505598d-8d76-4c86-9edd-da7959f9ef81
- UUID:
-
uuid:3505598d-8d76-4c86-9edd-da7959f9ef81
- Local pid:
- pubs:732517
- Paper number:
- 10111
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- © 2017 Jin, et al. Published by Elsevier Ltd.
- Copyright date:
- 2017
- Notes:
- This is an open access article published under a creative commons licence, see: https://creativecommons.org/licenses/by/4.0/
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