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Journal article

Process of Assay Selection and Optimization for the Study of Case and Control Samples from a Phase IIb Efficacy Trial of a Candidate Tuberculosis Vaccine, MVA85A

Abstract:

The first phase IIb safety and efficacy trial of a new tuberculosis vaccine since that for BCG was completed in October 2012. BCG-vaccinated South African infants were randomized to receive modified vaccinia virus Ankara, expressing the Mycobacterium tuberculosis antigen 85A (MVA85A), or placebo. MVA85A did not significantly boost the protective effect of BCG. Cryopreserved samples provide a unique opportunity for investigating the correlates of the risk of tuberculosis disease in this popula...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/cvi.00128-14

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Oxford college:
Green Templeton College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Clinical and Vaccine Immunology Journal website
Volume:
21
Issue:
7
Pages:
1005-1011
Publication date:
2014-06-30
Acceptance date:
2014-05-09
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
Source identifiers:
465040
Language:
English
Pubs id:
pubs:465040
UUID:
uuid:325a4ed8-622c-436f-bd16-2d5260cc8c92
Local pid:
pubs:465040
Deposit date:
2014-06-16

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