Thesis
The structural basis of immune receptor signalling
- Abstract:
-
This work investigates the mechanisms of binding of T cell receptors (TCRs) to Class I MHC-peptide complexes (pMHC). The structure of a TCR specific for the Melan-A tumour antigen bound to its cognate pMHC was solved to a resolution of 2.5 Å which gives insight into how this TCR could be mutated to optimize binding and subsequently used as a cancer vaccine. Detailed sequence and geometric analyses of all currently available structures of Class I TCR-pMHC complexes revealed that TCRs can bin...
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Authors
Contributors
+ Jones, E
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2008
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:32312040-2e22-4fe3-b05e-6f868233e27e
- Local pid:
- ora:1775
- Deposit date:
- 2008-03-14
Terms of use
- Copyright holder:
- Rebecca Hamer
- Copyright date:
- 2007
- Notes:
- Some material has been removed from the thesis for copyright reasons.
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