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UTRN on chromosome 6q24 is mutated in multiple tumors.

Abstract:

Though deletion of the long arm of chromosome 6 is one of the most common aberrations in tumors, its targeted gene(s) has not been convincingly identified. Using a functional screening approach, we found that UTRN (which encodes utrophin, a dystrophin-related protein) at 6q24, when expressed in an antisense orientation, induced cellular transformation, consistent with a tumor suppressor role. Northern blot analysis, semiquantitative reverse transcription-polymerase chain reaction (RT-PCR), an...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1210432

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Journal:
Oncogene
Volume:
26
Issue:
42
Pages:
6220-6228
Publication date:
2007-09-01
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
Source identifiers:
106804

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