Thesis
Analysis of nucleotide synthesis and homologous recombination repair in Schizosaccharomyces pombe
- Abstract:
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Nucleotide synthesis is a conserved and highly regulated response to DNA damage, required for the efficient repair of DNA double strand breaks (DSB) by homologous recombination (HR). This is essential to prevent loss of heterozygosity (LOH) and maintain genome stability. The aim of this study was to identify new genes important for HR through roles in damage-induced nucleotide synthesis. A screen was performed to identify S. pombe gene deletion strains whose DSB sensitivity was su...
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Authors
Contributors
+ Humphrey, T
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Blaikley, E
Grant:
G1000402-1/1
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:2fcd2cab-e8bc-4164-8068-5c50af5f91e4
- Local pid:
- ora:10003
- Deposit date:
- 2015-02-10
Terms of use
- Copyright holder:
- Blaikley, E
- Copyright date:
- 2014
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