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Mutant IDH1 promotes glioma formation in vivo

Abstract:

Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated gene in grade II-III glioma and secondary glioblastoma (GBM). A causal role for IDH1R132H in gliomagenesis has been proposed, but functional validation in vivo has not been demonstrated. In this study, we assessed the role of IDH1R132H in glioma development in the context of clinically relevant cooperating genetic alterations in vitro and in vivo. Immortal astrocytes expressing IDH1R132H exhibited elevated (R)-2-hydroxyglutarate l...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2018.03.133

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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
23
Issue:
5
Pages:
1553-1564
Publication date:
2018-05-02
Acceptance date:
2018-03-29
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pmid:
29719265
Source identifiers:
846356
Language:
English
Keywords:
Pubs id:
pubs:846356
UUID:
uuid:2f1a94bd-b4d9-4909-8e80-e3ec256a82e6
Local pid:
pubs:846356
Deposit date:
2018-06-20

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