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Knockout mice for dyslexia susceptibility gene homologs KIAA0319 and KIAA0319L have unaffected neuronal migration but display abnormal auditory processing

Abstract:

Developmental dyslexia is a neurodevelopmental disorder that affects reading ability caused by genetic and non-genetic factors. Amongst the susceptibility genes identified to date, KIAA0319 is a prime candidate. RNA-interference experiments in rats suggested its involvement in cortical migration but we could not confirm these findings in Kiaa0319- mutant mice (Martinez-Garay et al. 2017). Given its homologous gene Kiaa0319L (AU040320) has also been proposed to play a role in neuron...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cercor/bhx269

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Department:
Oxford, Medical Sciences Division, Physiology Anatomy & Genetics
Role:
Author
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Funding agency for:
Monaco, AP
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Funding agency for:
Linden, JF
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Funding agency for:
Velayos Baeza, A
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Funding agency for:
Molnar, Z
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Publisher:
Oxford University Press Publisher's website
Journal:
Cerebral Cortex Journal website
Volume:
27
Issue:
12
Pages:
5831–5845
Publication date:
2017-10-17
Acceptance date:
2017-09-19
DOI:
EISSN:
1060-2199
ISSN:
1047-3211
Pubs id:
pubs:732427
URN:
uri:2f078f67-85d7-40d1-92f9-fc65d95192cf
UUID:
uuid:2f078f67-85d7-40d1-92f9-fc65d95192cf
Local pid:
pubs:732427

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