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The making and breaking of SAS-6: structural insights and inhibitor search for n-terminal domain dimerisation

Abstract:

SAS-6 is the structural core of the forming centriole - a cylindrical protein complex, which is an essential component of the centrosome. Oligomerisation of SAS-6 is crucial for successful centriole duplication and is achieved through two dimerisation domains in the SAS-6 protein; a long C-terminal coiled-coil domain and a globular N-terminal dimerisation domain. As core components of the centrosome, centrioles help facilitate various cellular functions. They are involved in the anchoring ...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
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Funding agency for:
Busch, J
Grant:
1360448
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:2d5e4713-e645-40e9-87a1-88a7425d93eb
Deposit date:
2018-08-28

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