Thesis
The making and breaking of SAS-6: structural insights and inhibitor search for n-terminal domain dimerisation
- Abstract:
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SAS-6 is the structural core of the forming centriole - a cylindrical protein complex, which is an essential component of the centrosome. Oligomerisation of SAS-6 is crucial for successful centriole duplication and is achieved through two dimerisation domains in the SAS-6 protein; a long C-terminal coiled-coil domain and a globular N-terminal dimerisation domain. As core components of the centrosome, centrioles help facilitate various cellular functions. They are involved in the anchoring ...
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Authors
Contributors
+ Vakonakis, I
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Biggin, P
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:2d5e4713-e645-40e9-87a1-88a7425d93eb
- Deposit date:
- 2018-08-28
Terms of use
- Copyright holder:
- Busch, J; . Julia Maria Christiane Busch
- Copyright date:
- 2017
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