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The making and breaking of SAS-6: structural insights and inhibitor search for n-terminal domain dimerisation

Abstract:

SAS-6 is the structural core of the forming centriole - a cylindrical protein complex, which is an essential component of the centrosome. Oligomerisation of SAS-6 is crucial for successful centriole duplication and is achieved through two dimerisation domains in the SAS-6 protein; a long C-terminal coiled-coil domain and a globular N-terminal dimerisation domain. As core components of the centrosome, centrioles help facilitate various cellular functions. They are involved in the anchoring ...

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Department:
Oxford, MSD, Biochemistry
Role:
Author, Copyright Holder

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Department:
University of Oxford, Biochemistry
Role:
Supervisor
Department:
University of Oxford, Biochemistry
Role:
Supervisor
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Grant:
1360448
Funding agency for:
Julia Maria Christiane Busch
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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