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Journal article

The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study

Abstract:

Aims/Hypothesis:
Circulating succinate and 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) were recently shown to promote brown adipocyte thermogenesis and protect against metabolic disorders in rodents. This study aimed to evaluate the associations between plasma levels of these metabolites and adiposity and metabolic profile in humans.


Methods:
Fasting plasma succinate and 12,13-diHOME levels were quantified using ultra HPLC...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00125-019-4947-5

Authors


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Institution:
University of Oxford
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Publisher:
Springer Publisher's website
Journal:
Diabetologia Journal website
Volume:
62
Pages:
2079-2087
Publication date:
2019-07-15
Acceptance date:
2019-06-03
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Source identifiers:
1005319
Language:
English
Keywords:
Pubs id:
pubs:1005319
UUID:
uuid:2d21d152-442f-4b71-b244-42358a61868c
Local pid:
pubs:1005319
Deposit date:
2019-06-03

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