Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: antibody characterisation and a semi-quantitative western blot study.
Background Metabotropic glutamate receptor 3 (mGlu3, mGluR3), encoded by GRM3, is a risk gene for schizophrenia and a therapeutic target. It is unclear whether expression of the receptor is altered in the disorder or related to GRM3 risk genotype. Antibodies used to date to assess mGlu3 in schizophrenia have not been well validated. Objective To characterise six commercially available anti-mGlu3 antibodies for use in human brain, and then conduct a semi-quan... Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Copyright holder:
- García-Bea et al.
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Copyright © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
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