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Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: antibody characterisation and a semi-quantitative western blot study.

Abstract:
Background Metabotropic glutamate receptor 3 (mGlu3, mGluR3), encoded by GRM3, is a risk gene for schizophrenia and a therapeutic target. It is unclear whether expression of the receptor is altered in the disorder or related to GRM3 risk genotype. Antibodies used to date to assess mGlu3 in schizophrenia have not been well validated. Objective To characterise six commercially available anti-mGlu3 antibodies for use in human brain, and then conduct a semi-quan... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.schres.2016.04.015

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Fundación Alfonso Martín Escudero More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Schizophrenia Research Journal website
Publication date:
2016-01-01
Acceptance date:
2016-04-11
DOI:
ISSN:
1573-2509
Source identifiers:
615280
Keywords:
Pubs id:
pubs:615280
UUID:
uuid:2cea2edc-eab4-48b4-a751-bc148511fb7e
Local pid:
pubs:615280
Deposit date:
2016-04-14

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