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Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero

Abstract:

Gestational transfer of maternal antibodies against fetal neuronal proteins may be relevant to some neurodevelopmental disorders, but until recently there were no proteins identified. We recently reported a fivefold increase in CASPR2-antibodies in mid-gestation sera from mothers of children with intellectual and motor disabilities. Here, we exposed mice in utero to purified IgG from patients with CASPR2-antibodies (CASPR2-IgGs) or from healthy controls (HC-IgGs). CASPR2-IgG but not HC-IgG bo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00401-017-1751-5

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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More from this funder
Funding agency for:
West, S
Grant:
MR/M02394X/1
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Funding agency for:
West, S
Grant:
MR/M02394X/1
More from this funder
Funding agency for:
Domingos, J
More from this funder
Funding agency for:
Bennett, D
Grant:
MR/M02394X/1
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Publisher:
Springer Verlag Publisher's website
Journal:
Acta Neuropathologica Journal website
Volume:
134
Issue:
4
Pages:
567-583
Publication date:
2017-07-28
Acceptance date:
2017-07-13
DOI:
EISSN:
1432-0533
ISSN:
0001-6322
Keywords:
Pubs id:
pubs:708224
UUID:
uuid:2c6fe1ea-0420-417c-bf93-cf2fc1434afe
Local pid:
pubs:708224
Deposit date:
2017-07-27

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