Journal article
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
- Abstract:
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The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying by ancestry, we analysed genotyped and imputed variants in Melanesians (607 cases and 1,229 controls) before follow-up of suggestive loci in three further ancestral groups: Polynesians, South Asians and Mixed or other populations (totalling 3...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
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- Files:
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(pdf, 966.5KB)
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- Publisher copy:
- 10.1038/ncomms14946
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Authors
Funding
+ British Heart Foundation
More from this funder
Funding agency for:
Parks, T
Grant:
Josephine Lansdell Grant 2012
+ Medical Research Council
More from this funder
Funding agency for:
Parks, T
Grant:
Josephine Lansdell Grant 2012
+ British Medical Association
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Funding agency for:
Parks, T
Grant:
Josephine Lansdell Grant 2012
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Nowak, J
Grant:
EP/G037280/1
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Pages:
- 14946
- Publication date:
- 2017-05-01
- Acceptance date:
- 2017-02-15
- DOI:
- ISSN:
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2041-1723
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:695816
- UUID:
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uuid:2c2dc82b-53d2-4f92-a844-48f20d0b34ff
- Local pid:
- pubs:695816
- Deposit date:
- 2017-07-10
Terms of use
- Copyright holder:
- Deane et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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