Journal article icon

Journal article

The evolutionary history of 2,658 cancers

Abstract:

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)4, we reconstruct the life history ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41586-019-1907-7

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
Expand authors...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
578
Issue:
2020
Pages:
122-128
Publication date:
2020-02-05
Acceptance date:
2019-11-18
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
32025013
Language:
English
Keywords:
Pubs id:
1086332
Local pid:
pubs:1086332
Deposit date:
2020-04-07

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP