Journal article
Lipid loving ANTs: Molecular simulations of cardiolipin interactions and the organization of the adenine nucleotide translocase in model mitochondrial membranes
- Abstract:
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The exchange of ADP and ATP across the inner mitochondrial membrane is a fundamental cellular process. This exchange is facilitated by the adenine nucleotide translocase (ANT), the structure and function of which is critically dependent on the signature phospholipid of mitochondria, cardiolipin (CL). Here we employ multiscale molecular dynamics simulations to investigate CL interactions within a membrane environment. Using simulations at both coarse-grained (CG) and atomistic (AT) resolutions...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 5.7MB)
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- Publisher copy:
- 10.1021/acs.biochem.6b00751
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Authors
Funding
Wellcome Trust
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Biotechnology and Biological Sciences Research Council
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Engineering and Physical Sciences Research Council
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European Union
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Biochemistry Journal website
- Volume:
- 55
- Issue:
- 45
- Pages:
- 6238–6249
- Publication date:
- 2016-10-05
- Acceptance date:
- 2016-10-27
- DOI:
- ISSN:
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1520-4995 and 0006-2960
- Pubs id:
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pubs:655571
- URN:
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uri:2b8f782e-e196-44b8-bc3f-30882feb0da6
- UUID:
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uuid:2b8f782e-e196-44b8-bc3f-30882feb0da6
- Local pid:
- pubs:655571
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2016
- Notes:
- © 2016 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
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