Thesis icon

Thesis

Studies on recently identified activities of the Jumonji-C oxygenase JMJD4 and the bacterial class D nucleophilic serine β-lactamases

Abstract:

The Jumonji-C oxygenase JMJD4 and the bacterial class D nucleophilic serine β-lactamases (SBLs) have been recently found to catalyse unprecedented cyclisation reactions. Biochemical, biophysical, and inhibition studies were carried out to investigate the formation of β-lactones from carbapenems by class D SBLs, and the JMJD4 catalysed γ-lactam ring formation of eukaryotic release factor 1 (eRF1). Chapter 1 gives an introduction to the β-lactamase and oxygenase enzyme families to which the ...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Oxford college:
St Hilda's College
Role:
Author

Contributors

Role:
Supervisor
More from this funder
Funding agency for:
Aertker, K
Grant:
EP/L016044/1
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Deposit date:
2022-01-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP