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A mechanistic evolutionary model explains the time-dependent pattern of substitution rates in viruses

Abstract:

Estimating viral timescales is fundamental in understanding the evolutionary biology of viruses. Molecular clocks are widely used to reveal the recent evolutionary histories of viruses but may severely underestimate their longer-term origins because of the inverse correlation between inferred rates of evolution and the timescale of their measurement. Here, we provide a predictive mechanistic model that readily explains the rate decay phenomenon over a wide range of timescales and recapitulate...

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Publication status:
In press
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cub.2021.08.020

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
St Hilda's College
Role:
Author
University College, Oxford More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Current Biology Journal website
Volume:
31
Issue:
21
Pages:
4689-4696.e5
Publication date:
2021-09-02
Acceptance date:
2021-08-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Pmid:
34478645

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