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Data for 'Light-Driven, Posttranslation Installation of Reactive Protein Side Chains'

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Subgroup:
Chemical Biology
Oxford college:
Hertford College
Role:
Depositor, Creator
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Grant:
EP/R512333/1
Programme:
Systems Approaches to Biomedical Science 45
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Grant:
FP/2007-2013)/ ERC Grant Agreement no. 320403
Programme:
European Union's Seventh Framework Programme
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Grant:
BB/P026311/1, B.G.D., V.G., P.G.I.
Publisher:
University of Oxford
Publication date:
2020
DOI:
Language:
English
Documentation:
C–C side chain alteration within intact proteins has the potential to allow native, chemical, post-translational modification mutagenesis (‘protein editing’) of sequences. Whilst 2e- heterolytic methods (via C-/C+) are highly limited in biological environments and molecules, radical (C•) methods have shown early promise due to apparently well-matched selectivities. However, current methods, reagents, and conditions for C• generation are either limited in site-selectivity and/or only partiall... Expand documentation

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