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Data for 'Light-Driven, Posttranslation Installation of Reactive Protein Side Chains'
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Authors/Creators
Funding
+ Oxford-GSK-Crick Chemical Biology Centre for Doctoral Training Programme (EPSRC and GSK)
More from this funder
Grant:
EP/R512333/1
Programme:
Systems Approaches to Biomedical Science 45
+ European Research Council
More from this funder
Grant:
FP/2007-2013)/ ERC Grant Agreement no. 320403
Programme:
European Union's Seventh Framework Programme
Bibliographic Details
- Publisher:
- University of Oxford
- Publication date:
- 2020
- DOI:
Item Description
- Language:
- English
- Documentation:
-
C–C side chain alteration within intact proteins has the potential to allow native, chemical, post-translational modification mutagenesis (‘protein editing’) of sequences. Whilst 2e- heterolytic methods (via C-/C+) are highly limited in biological environments and molecules, radical (C•) methods have shown early promise due to apparently well-matched selectivities. However, current methods, reagents, and conditions for C• generation are either limited in site-selectivity and/or only partiall... Expand documentation
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