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Prion protein codon 129 polymorphism in mild cognitive impairment and dementia: the Rotterdam Study

Abstract:

Creutzfeldt–Jakob disease is a rare, fatal, neurodegenerative disease caused by the accumulation of abnormally folded prion proteins. The common polymorphism at codon 129 (methionine/valine) in the prion protein (PRNP) gene is the most important determinant of genetic susceptibility. Homozygotes of either allele have a higher risk of sporadic Creutzfeldt–Jakob disease. Various studies suggest that this polymorphism is also involved in other forms of dementia. We studied the association betwee...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/braincomms/fcaa030

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NIA NIH HHS More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Communications Journal website
Volume:
2
Issue:
1
Article number:
fcaa030
Publication date:
2020-03-20
Acceptance date:
2020-02-17
DOI:
EISSN:
2632-1297
Pmid:
32954288
Language:
English
Keywords:
Pubs id:
1134946
Local pid:
pubs:1134946
Deposit date:
2020-12-02

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