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Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

Abstract:

BACKGROUND:Genome-wide association studies (GWAS) have identified several hundred susceptibility loci for type 2 diabetes (T2D). One critical, but unresolved, issue concerns the extent to which the mechanisms through which these diverse signals influencing T2D predisposition converge on a limited set of biological processes. However, the causal variants identified by GWAS mostly fall into a non-coding sequence, complicating the task of defining the effector transcripts through which they oper...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13073-019-0628-8

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Wellcome Trust Centre for Human Genetics
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
Genome medicine Journal website
Volume:
11
Article number:
19
Publication date:
2019-03-26
Acceptance date:
2019-03-08
DOI:
ISSN:
1756-994X
Pmid:
30914061
Source identifiers:
986932
Language:
English
Keywords:
Pubs id:
pubs:986932
UUID:
uuid:2915999d-6c35-4cad-93f1-f490463f8d7b
Local pid:
pubs:986932
Deposit date:
2019-04-09

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