Journal article
RNA polymerase pausing during initial transcription
- Abstract:
-
In bacteria, RNA polymerase (RNAP) initiates transcription by synthesizing short transcripts that are either released or extended to allow RNAP to escape from the promoter. The mechanism of initial transcription is unclear due to the presence of transient intermediates and molecular heterogeneity. Here, we studied initial transcription on a lac promoter using single-molecule fluorescence observations of DNA scrunching on immobilized transcription complexes. Our work revealed a long pause ("in...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Linacre College, Oxford
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Funding agency for:
Bauer, D
Grant:
EPAC Junior Research Fellowship
+ National Science Foundation
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Funding agency for:
Bauer, D
Grant:
EPAC Junior Research Fellowship
+ Biotechnology and Biological Sciences Research Council
More from this funder
Grant:
BB/H01795X/1
BB/J00054X/1
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Molecular cell Journal website
- Volume:
- 63
- Issue:
- 6
- Pages:
- 939-950
- Publication date:
- 2016-09-03
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Pmid:
-
27618490
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:645858
- UUID:
-
uuid:288ee21f-f5ce-4fe4-b19b-2f1e5b45c6ef
- Local pid:
- pubs:645858
- Deposit date:
- 2017-05-20
Terms of use
- Copyright holder:
- Duchi et al
- Copyright date:
- 2016
- Notes:
-
Copyright © 2016 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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