Thesis
The analysis of homologous recombination pathways in Saccharomyces Cerevisiae
- Abstract:
-
Homologous recombination (HR) is essential for the repair of DNA doublestrand breaks (DSBs) and damaged replication forks. However, HR can also cause gross chromosomal rearrangements (GCRs) by producing crossovers (COs), resulting in the reciprocal exchange of sequences between non-sister chromatids. Therefore, HR-mediated GCRs are suppressed via the promotion of HR pathways that favour noncrossover (NCO) formation, such as the synthesis-dependent strand annealing (SDSA) and dissolution pa...
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Funding
Bibliographic Details
- Publication date:
- 2010
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:2832c80a-202d-4b92-9685-5570c25f7386
- Local pid:
- ora:11327
- Deposit date:
- 2015-04-30
Terms of use
- Copyright holder:
- Tay, Y
- Copyright date:
- 2010
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