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Cavitational mechanisms in ultrasound-accelerated fibrinolysis

Abstract:

The role of both inertial and stable cavitation was investigated during in vitro ultrasound-accelerated fibrinolysis by recombinant tissue plasminogen activator (rt-PA) in the presence and absence of Optison™. A unique treatment configuration applied ultrasound, rt-PA and Optison™ to the interior of a plasma clot. Lysis efficacy was measured as clot weight reduction. Cavitational mechanisms were investigated by monitoring subharmonic and broadband noise. In the absence of Optison™, 1.7 MHz pu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ultrasmedbio.2006.11.022

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
Harris Manchester College
Role:
Author
ORCID:
0000-0001-6394-5667
Publisher:
Elsevier Publisher's website
Journal:
Ultrasound in Medicine and Biology Journal website
Volume:
33
Issue:
6
Pages:
924-933
Publication date:
2007-04-16
Acceptance date:
2006-11-28
DOI:
EISSN:
1879-291X
ISSN:
0301-5629
Pmid:
17434661
Source identifiers:
430569
Language:
English
Keywords:
Pubs id:
pubs:430569
UUID:
uuid:27bff91a-c7d2-4d2f-9ab8-16e213b3d14f
Local pid:
pubs:430569
Deposit date:
2018-12-03

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