Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats.
To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuV(JL5)), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the genomic background of MuV(JL5) Cross-reactivity and cross-neutralization between this chimeric rMuV(JL5)-F/HN(BMV) virus and rMuV(JL5) were demonstrated using hyperimmune mouse sera and a curated panel of human sera. All mouse and human sera that were able to neutralize rMuV(JL5) infection had cr...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Accepted manuscript, pdf, 1.2MB)
- Publisher copy:
- Copyright holder:
- Bowden et al
- Copyright date:
- © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail email@example.com.
If you are the owner of this record, you can report an update to it here: Report update to this record