Journal article
Assessment of selected media supplements to improve F/HN lentiviral vector production yields
- Abstract:
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The development of lentiviral-based therapeutics is challenged by the high cost of current Good Manufacturing Practices (cGMP) production. Lentiviruses are enveloped viruses that capture a portion of the host cell membrane during budding, which then constitutes part of the virus particle. This process might lead to lipid and protein depletion in the cell membrane and affect cell viability. Furthermore, growth in suspension also causes stresses that can affect virus production yields. To asses...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 661.6KB)
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(Version of record, pdf, 1.6MB)
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- Publisher copy:
- 10.1038/s41598-017-07893-3
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Authors
Funding
+ Clarendon Fund
More from this funder
Funding agency for:
Gélinas, J
Grant:
Doctoral Foreign Study Award
+ Keble College, Oxford
More from this funder
Funding agency for:
Gélinas, J
Grant:
Doctoral Foreign Study Award
+ Canadian Institutes of Health Research
More from this funder
Funding agency for:
Gélinas, J
Grant:
Doctoral Foreign Study Award
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Pages:
- 10198
- Publication date:
- 2017-08-31
- Acceptance date:
- 2017-05-31
- DOI:
- EISSN:
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2045-2322
- ISSN:
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2045-2322
- Source identifiers:
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698713
Item Description
- Pubs id:
-
pubs:698713
- UUID:
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uuid:21930b5f-6703-4beb-990e-456962af688a
- Local pid:
- pubs:698713
- Deposit date:
- 2017-06-08
Terms of use
- Copyright holder:
- Gélinas et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. A correction was added to this record on 10 August 2018
- Licence:
- CC Attribution (CC BY)
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