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The effects of neuroinflammation on the subventricular zone neurogenic compartment following Theiler's Murine Encephalomyelitis virus infection and its regulation by Galectin-3

Abstract:

The subventricular zone (SVZ) is an adult neurogenic niche that contains multipotent stem/progenitor cells that may be a viable target for remyelination in Multiple Sclerosis. In response to demyelination, SVZ progenitors are recruited into myelin lesions. Currently, the effect of inflammation on the endogenous brain stem cell compartment remains poorly characterised. Theiler's murine encephalomyelitis virus (TMEV) induces a demyelinating disease in susceptible SJL/J mice, due to persisten...

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Authors


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Institution:
University of Oxford
Division:
MSD
Research group:
Dr Francis Szele
Oxford college:
St Cross College
Role:
Author

Contributors

Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
More from this funder
Funding agency for:
James, RE
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:1d124967-3447-4c23-a212-965a8bc0e845
Local pid:
ora:11503
Deposit date:
2015-05-28

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