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Thesis

Screen for proteins that regulate sensitivity to inhibition of the insulin-like growth factor 1 receptor

Abstract:

The type 1 insulin-like growth factor receptor (IGF-1R) plays a significant role in tumor growth and spread, and IGF-1R inhibitors and antibodies are now undergoing clinical testing. However, factors that regulate sensitivity to IGF-1R inhibition remain unclear. The aim of this project is to identify proteins whose depletion regulates sensitivity to IGF-1R inhibition, in order to design effective combination treatments to benefit patients. An IGF-1R kinase inhibitor, AZ12253801 (provided b...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Oxford college:
Wolfson College
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:1cd34ec7-aaaa-46c1-98ee-a2b81c73d6a8
Deposit date:
2016-11-15

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