Thesis
Screen for proteins that regulate sensitivity to inhibition of the insulin-like growth factor 1 receptor
- Abstract:
-
The type 1 insulin-like growth factor receptor (IGF-1R) plays a significant role in tumor growth and spread, and IGF-1R inhibitors and antibodies are now undergoing clinical testing. However, factors that regulate sensitivity to IGF-1R inhibition remain unclear. The aim of this project is to identify proteins whose depletion regulates sensitivity to IGF-1R inhibition, in order to design effective combination treatments to benefit patients. An IGF-1R kinase inhibitor, AZ12253801 (provided b...
Expand abstract
Actions
Access Document
- Files:
-
-
(pdf, 47.6MB)
-
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:1cd34ec7-aaaa-46c1-98ee-a2b81c73d6a8
- Deposit date:
- 2016-11-15
Terms of use
- Copyright holder:
- Gao, S
- Copyright date:
- 2012
If you are the owner of this record, you can report an update to it here: Report update to this record