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Multiple lipid binding sites determine the affinity of PH domains for phosphoinositide-containing membranes

Abstract:

Association of peripheral proteins with lipid bilayers regulates membrane signaling and dynamics. Pleckstrin homology (PH) domains bind to phosphatidylinositol phosphate (PIP) molecules in membranes. The effects of local PIP enrichment on the interaction of PH domains with membranes is unclear. Molecular dynamics simulations allow estimation of the binding energy of GRP1 PH domain to PIP3-containing membranes. The free energy of interaction of the PH domain with more than two PI...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/sciadv.aay5736

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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
6
Issue:
8
Article number:
eaay5736
Publication date:
2020-02-19
Acceptance date:
2019-11-12
DOI:
EISSN:
2375-2548
Source identifiers:
1071321
Language:
English
Keywords:
Pubs id:
pubs:1071321
UUID:
uuid:1cca4f97-d71a-4748-9246-b1b30424f6e4
Local pid:
pubs:1071321
Deposit date:
2019-11-12

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