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Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

Abstract:

HERV-K HML-2 (HK2) has been proliferating in the germ line of humans at least as recently as 250,000 years ago, with some integrations that remain polymorphic in the modern human population. One of the solitary HK2 LTR polymorphic integrations lies between exons 17 and 18 of RASGRF2, a gene that affects dopaminergic activity and is thus related to addiction. Here we show that this antisense HK2 integration (namely RASGRF2-int) is found more frequently in persons who inject drugs compared with...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1811940115

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Funding agency for:
McLauchlan, J
Grant:
MC_UU_12014/1
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
41
Pages:
10434-10439
Publication date:
2018-09-24
Acceptance date:
2018-08-23
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
922588
Keywords:
Pubs id:
pubs:922588
UUID:
uuid:1cc36c27-5bf7-462a-9561-20ed9538acb9
Local pid:
pubs:922588
Deposit date:
2018-10-01

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