Journal article
Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model
- Abstract:
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HERV-K HML-2 (HK2) has been proliferating in the germ line of humans at least as recently as 250,000 years ago, with some integrations that remain polymorphic in the modern human population. One of the solitary HK2 LTR polymorphic integrations lies between exons 17 and 18 of RASGRF2, a gene that affects dopaminergic activity and is thus related to addiction. Here we show that this antisense HK2 integration (namely RASGRF2-int) is found more frequently in persons who inject drugs compared with...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 597.1KB)
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- Publisher copy:
- 10.1073/pnas.1811940115
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Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
McLauchlan, J
Grant:
MC_UU_12014/1
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 115
- Issue:
- 41
- Pages:
- 10434-10439
- Publication date:
- 2018-09-24
- Acceptance date:
- 2018-08-23
- DOI:
- EISSN:
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1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
922588
Item Description
- Keywords:
- Pubs id:
-
pubs:922588
- UUID:
-
uuid:1cc36c27-5bf7-462a-9561-20ed9538acb9
- Local pid:
- pubs:922588
- Deposit date:
- 2018-10-01
Terms of use
- Copyright holder:
- National Academy of Sciences
- Copyright date:
- 2018
- Notes:
- © 2018 Published under the PNAS license. This is the accepted manuscript version of the article. The final version is available online from National Academy of Sciences at: https://doi.org/10.1073/pnas.1811940115
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