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Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4

Abstract:

Rhomboid-like proteins are evolutionarily conserved, ubiquitous polytopic membrane proteins, including the canonical rhomboid intramembrane serine proteases and also others that have lost protease activity during evolution. We still have much to learn about their cellular roles, and evidence suggests that some may have more than one function. For example, rhomboid-like protein 4 (RHBDL4) is an endoplasmic reticulum (ER)-resident protease that forms a ternary complex with ubiquitinated substra...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.ra118.007074

Authors


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Role:
Author
ORCID:
0000-0002-4962-0767
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Lincoln College
Role:
Author
ORCID:
0000-0003-0410-5451
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
294
Issue:
30
Pages:
11486-11497
Publication date:
2019-06-07
Acceptance date:
2019-06-07
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
31177093
Source identifiers:
1014208

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