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Journal article

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Abstract:

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6,7,8,9,10,11. In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41588-018-0307-5

Authors


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Role:
Author
ORCID:
0000-0002-3108-7087
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Role:
Author
ORCID:
0000-0002-1163-3634
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Institution:
University of Oxford
Division:
Social Sciences Division
Department:
Sociology
Department:
Unknown
Role:
Author
ORCID:
0000-0001-5361-2498
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
51
Issue:
2
Pages:
237-244
Publication date:
2019-01-14
Acceptance date:
2018-11-06
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pmid:
30643251
Source identifiers:
963305
Language:
English
Keywords:
Pubs id:
pubs:963305
UUID:
uuid:1cb67b64-cc43-4eea-8aa0-aeca642843e7
Local pid:
pubs:963305
Deposit date:
2019-04-05

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