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Transgenic zebrafish model for quantification and visualization of tissue toxicity caused by alloying elements in newly developed biodegradable metal

Abstract:

The cytotoxicity of alloying elements in newly developed biodegradable metals can be assessed through relatively low-cost and rapid in vitro studies using different cell types. However, such approaches have limitations; as such, additional investigations in small mammalian models are required that recapitulate the physiological environment. In this study, we established a zebrafish (Danio rerio) model for cytotoxicity evaluations that combines the physiological aspects of an animal model with...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-018-32313-5

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0001-6870-1485
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
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Funding agency for:
Han, H
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Funding agency for:
Edwards, J
Grant:
20631
Ministry of Trade, Industry and Energy More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
13818
Publication date:
2018-09-14
Acceptance date:
2018-09-04
DOI:
EISSN:
2045-2322
Source identifiers:
916022
Keywords:
Pubs id:
pubs:916022
UUID:
uuid:1ba61b57-22d4-4375-9f87-a4c4bc9c62c7
Local pid:
pubs:916022
Deposit date:
2018-09-10

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