Thesis
Preparing and sequencing ultra-long DNA molecules from single chromosomes
- Abstract:
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In this thesis, I describe the development of a single-molecule platform for analysing long DNA molecules that captures haplotype and large-scale structural variation (SV) in addition to DNA sequence. Current DNA sequencing methods cannot adequately examine haplotype and SV – both contribute to biological function and disease and are candidates for the location of "missing heritability" in the genome. Both haplotype and SV fundamentally relate to the structure of single chromosomes.
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Funding
+ Rhodes Trust, NDM, US National Science Foundation
More from this funder
Funding agency for:
Bauer, D
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:1b489b74-6515-4118-9560-dbf44f1bc276
- Deposit date:
- 2016-11-15
Terms of use
- Copyright holder:
- David L.V. Bauer
- Copyright date:
- 2013
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