Journal article
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix
- Abstract:
-
Citrullination of proteins, a post-translational conversion of arginine residues to citrulline, is recognized in rheumatoid arthritis, but largely undocumented in cancer. Here we show that citrullination of the extracellular matrix by cancer cell derived peptidylarginine deiminase 4 (PAD4) is essential for the growth of liver metastases from colorectal cancer (CRC). Using proteomics, we demonstrate that liver metastases exhibit higher levels of citrullination and PAD4 than unaffected liver, p...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature communications Journal website
- Volume:
- 9
- Article number:
- 4783
- Publication date:
- 2018-11-14
- Acceptance date:
- 2018-10-22
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
30429478
Item Description
- Language:
- English
- Pubs id:
-
pubs:942832
- UUID:
-
uuid:1aea7343-3f0f-4038-9025-647275230067
- Local pid:
- pubs:942832
- Deposit date:
- 2018-12-06
Terms of use
- Copyright holder:
- Yuzhalin et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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