Journal article
Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
- Abstract:
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Background
Intratumoural T-cell infiltrate intensity cortes wrelaith clinical outcome in stage II/III colorectal cancer (CRC). We aimed to determine whether this association varies across this heterogeneous group.
Methods
We performed a pooled analysis of 1804 CRCs from the QUASAR2 and VICTOR trials. Intratumoural CD8+ and CD3+ densities were quantified by immunohistochemistry in tissue microarray (TMA) cores, and their association with clinical outcome analysed...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Health Foundation/Academy of Medical Sciences
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Funding agency for:
Church, D
Grant:
Clinician Scientist Fellowship
+ Wellcome Trust
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Grant:
090532/Z/09/Z
Clinical Training Fellowship
Funding agency for:
Glaire, MA
Oxford Cancer Centre
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- British Journal of Cancer Journal website
- Volume:
- 121
- Pages:
- 474-482
- Publication date:
- 2019-08-07
- Acceptance date:
- 2019-07-18
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
Item Description
- Keywords:
- Pubs id:
-
pubs:1030348
- UUID:
-
uuid:1a7063af-69fa-4d8b-a174-a4fc1d25f860
- Local pid:
- pubs:1030348
- Source identifiers:
-
1030348
- Deposit date:
- 2019-07-09
Terms of use
- Copyright holder:
- Glaire et al
- Copyright date:
- 2019
- Notes:
-
© The Author(s) 2019
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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