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Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

Abstract:

Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose in type-2 diabetes remain unresolved. Using a combination of transcriptomics and proteomics, we find significant dysregulation of major metabolic pathways in islets of diabetic βV59M mice, a non-obese, eulipidaemic diabetes model. Multiple genes/proteins involved in glycol...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-10189-x

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Role:
Author
ORCID:
0000-0003-3097-9240
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Role:
Author
ORCID:
0000-0003-3926-1534
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Role:
Author
ORCID:
0000-0002-8883-176X
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Issue:
1
Article number:
2474
Publication date:
2019-06-06
Acceptance date:
2019-04-12
DOI:
ISSN:
2041-1723
Pmid:
31171772
Source identifiers:
1010746
Language:
English
Keywords:
Pubs id:
pubs:1010746
UUID:
uuid:1a5686ab-99d0-4fe8-9f4b-1a8578198c3a
Local pid:
pubs:1010746
Deposit date:
2019-06-21

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