Journal article
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
- Abstract:
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Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose in type-2 diabetes remain unresolved. Using a combination of transcriptomics and proteomics, we find significant dysregulation of major metabolic pathways in islets of diabetic βV59M mice, a non-obese, eulipidaemic diabetes model. Multiple genes/proteins involved in glycol...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.3MB)
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- Publisher copy:
- 10.1038/s41467-019-10189-x
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 10
- Issue:
- 1
- Article number:
- 2474
- Publication date:
- 2019-06-06
- Acceptance date:
- 2019-04-12
- DOI:
- ISSN:
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2041-1723
- Pmid:
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31171772
- Source identifiers:
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1010746
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1010746
- UUID:
-
uuid:1a5686ab-99d0-4fe8-9f4b-1a8578198c3a
- Local pid:
- pubs:1010746
- Deposit date:
- 2019-06-21
Terms of use
- Copyright holder:
- Haythorne et al
- Copyright date:
- 2019
- Notes:
-
© The Author(s) 2019. This article is licensed under a Creative Commons
Attribution 4.0 International License
- Licence:
- CC Attribution (CC BY)
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