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Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

Abstract:
We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPF-ERCC1, with a view to accelerating inhibitor and drug discovery.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/C9CC05476F

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Wolfson College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Funding agency for:
Thomas, A
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Funding agency for:
El-Sagheer, A
Grant:
BB/R008655/1
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Funding agency for:
Ptchelkine, D
Grant:
MR/R009368/1
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Funding agency for:
McHugh, P
Grant:
MR/R009368/1
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Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications Journal website
Volume:
55
Issue:
78
Pages:
11671-11674
Publication date:
2019-09-09
Acceptance date:
2019-08-15
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Source identifiers:
1045711
Pubs id:
pubs:1045711
UUID:
uuid:197cdc0f-fe3e-4756-ac9c-a456d77b56a8
Local pid:
pubs:1045711
Deposit date:
2019-08-16

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