Journal article
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors
- Abstract:
- We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPF-ERCC1, with a view to accelerating inhibitor and drug discovery.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
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(Version of record, pdf, 2.6MB)
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(Version of record, pdf, 1.4MB)
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- Publisher copy:
- 10.1039/C9CC05476F
Authors
Funding
+ Medical Research Council
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Funding agency for:
Ptchelkine, D
McHugh, P
Brolih, S
Grant:
MR/R009368/1
MR/R009368/1
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Thomas, A
El-Sagheer, A
Grant:
BB/R008655/1
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Thomas, A
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Communications Journal website
- Volume:
- 55
- Issue:
- 78
- Pages:
- 11671-11674
- Publication date:
- 2019-09-09
- Acceptance date:
- 2019-08-15
- DOI:
- EISSN:
-
1364-548X
- ISSN:
-
1359-7345
Item Description
- Pubs id:
-
pubs:1045711
- UUID:
-
uuid:197cdc0f-fe3e-4756-ac9c-a456d77b56a8
- Local pid:
- pubs:1045711
- Source identifiers:
-
1045711
- Deposit date:
- 2019-08-16
Terms of use
- Copyright holder:
- Thomas et al
- Copyright date:
- 2019
- Notes:
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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