Journal article
A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and Type 2 Diabetes risk.
- Abstract:
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To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in AKT2 and fasting insulin, a gene in which rare fully penetrant mutations are...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
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- Files:
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(pdf, 6.1MB)
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- Publisher copy:
- 10.2337/db16-1329
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Authors
Funding
Academy of Finland
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Action on Hearing Loss
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Ahokas Foundation
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American Diabetes Association
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Atlantic Canada Opportunities Agency
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Bibliographic Details
- Publisher:
- American Diabetes Association Publisher's website
- Journal:
- Diabetes Journal website
- Publication date:
- 2017-03-05
- Acceptance date:
- 2017-03-13
- DOI:
- EISSN:
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1939-327X
- ISSN:
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0012-1797
- Pubs id:
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pubs:687297
- URN:
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uri:18c8992b-2055-4a17-91a7-12463fcd91ea
- UUID:
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uuid:18c8992b-2055-4a17-91a7-12463fcd91ea
- Local pid:
- pubs:687297
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- American Diabetes Association
- Copyright date:
- 2017
- Notes:
- © 2017 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.
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