Thesis icon

Thesis

The role of tryptophan and the mTOR pathway in T cell fate determination

Abstract:

The adaptive immune response forms an essential part of the cancer immuno-editing process, whereby nascent malignant cells are detected and destroyed prior to forming tumours. The process is tightly controlled to minimise collateral damage to healthy tissue. One of the mechanisms evolved for this purpose and frequently co-opted by malignant cells is the creation of a microenvironment scarce in essential amino-acids through the use of catabolic enzymes such as Indoleamine 2,3-dioxygenase (I...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Tumour Immunology Group
Oxford college:
Wolfson College
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:1831d28b-52cb-47ee-8047-f6044cd10301
Local pid:
ora:11702
Deposit date:
2015-06-22

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP