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Generating the evidence for typhoid vaccine introduction: Considerations for global disease burden estimates and vaccine testing through human challenge

Abstract:

Typhoid fever has had a major impact on human populations, with the causative pathogen Salmonella enterica serovar Typhi implicated in many outbreaks through history. The current burden of disease is estimated at 11–18 million infections annually, with the majority of infections located in Africa and South Asia. Data that have been used to estimate burden are limited to a small number of blood-culture surveillance studies, largely from densely populated urban centers. Extrapolating these data...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cid/ciz630

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Oxford college:
St Hilda's College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
HUMS
Department:
Philosophy Faculty
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Humanities Division
Department:
Philosophy
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0001-7361-719X
Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
69
Issue:
Supplement_5
Pages:
S402-S407
Publication date:
2019-10-15
Acceptance date:
2019-07-08
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pmid:
31612941
Source identifiers:
1063802
Language:
English
Keywords:
Pubs id:
pubs:1063802
UUID:
uuid:17a0a0d6-0a61-4d41-ae25-0880a8d3edda
Local pid:
pubs:1063802
Deposit date:
2019-10-30

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