Journal article
UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity
- Abstract:
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Accurate DNA replication is critical for the maintenance of genome integrity and cellular survival. Cancer-associated alterations often involve key players of DNA replication and of the DNA damage-signalling cascade. Post-translational modifications play a fundamental role in coordinating replication and repair and central among them is ubiquitylation. We show that the E3 ligase UBR5 interacts with components of the replication fork, including the translesion synthesis (TLS) polymerase polη. ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 6.8MB)
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- Publisher copy:
- 10.1093/nar/gkz824
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Authors
Funding
John Fell Fund
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 47
- Issue:
- 21
- Pages:
- 11268-11283
- Publication date:
- 2019-10-05
- Acceptance date:
- 2019-09-25
- DOI:
- EISSN:
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1362-4962
- ISSN:
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0305-1048
- Source identifiers:
-
1058600
Item Description
- Language:
- English
- Pubs id:
-
pubs:1058600
- UUID:
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uuid:17145a1a-a104-47b4-aeff-9fb879c91b5e
- Local pid:
- pubs:1058600
- Deposit date:
- 2019-09-29
Terms of use
- Copyright holder:
- Cipolla et al.
- Copyright date:
- 2019
- Rights statement:
- © The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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