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Journal article

UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity

Abstract:

Accurate DNA replication is critical for the maintenance of genome integrity and cellular survival. Cancer-associated alterations often involve key players of DNA replication and of the DNA damage-signalling cascade. Post-translational modifications play a fundamental role in coordinating replication and repair and central among them is ubiquitylation. We show that the E3 ligase UBR5 interacts with components of the replication fork, including the translesion synthesis (TLS) polymerase polη. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkz824

Authors


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Institution:
University of Oxford
Department:
Biochemistry
Role:
Author
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John Fell Fund More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
47
Issue:
21
Pages:
11268-11283
Publication date:
2019-10-05
Acceptance date:
2019-09-25
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Source identifiers:
1058600
Language:
English
Pubs id:
pubs:1058600
UUID:
uuid:17145a1a-a104-47b4-aeff-9fb879c91b5e
Local pid:
pubs:1058600
Deposit date:
2019-09-29

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