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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

Abstract:

Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that reduce hypoxia in tumours, we conduct a high-throughput screen for oxygen consumption rate (OCR) reduction and identify a number of drugs with this property. For this study we focus on the anti-malarial, atovaquone. Atovaquone rapidly decreases the OCR by more than 80% in a wide range of cancer cell lines at pharmacological concentrations. I...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms12308

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
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Publisher:
Nature Publishing Group: Nature Communications Publisher's website
Journal:
Nature communications Journal website
Volume:
7
Pages:
12308
Publication date:
2016-07-25
Acceptance date:
2016-06-17
DOI:
ISSN:
2041-1723
Pmid:
27453292
Source identifiers:
636321
Language:
English
Subjects:
Pubs id:
pubs:636321
UUID:
uuid:15d89091-2bfd-4609-80fa-c5157ea5d1c9
Local pid:
pubs:636321
Deposit date:
2017-10-19

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